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KMID : 1094020200370040208
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Journal of Veterinary Clinics
2020 Volume.37 No. 4 p.208 ~ p.212
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Renal Lymphoma with Mesenteric Lymphomatosis in a Cat
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Jeon Jin-Ha
Song Doo-Won
Ro Woong-Bin
Kim Heyong-Seok
Lee Ga-Won
Cho Jun-Ho
Jeong Woo-Chang
Kim Soo-Hyeon
Sur Jung-Hyang
Park Hee-myung
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Abstract
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A 6-year-old castrated male Russian Blue cat was presented for evaluation of dyschezia. Abdominal
ultrasound revealed hyperechoic nodules in both kidneys, heterogeneous mass in abdomen, and extensive mesenteric
thickening with multiple hypoechoic nodules. Computed tomography showed multiple hypodense lesions in both kidneys
and diffuse nodular infiltration around the mesentery. Fine needle aspirates (FNA) acquired under ultrasound guidance
from the mesentery consisted of large lymphocytes which have round to irregular nuclei with granular chromatin,
prominent nucleoli and a small amount of basophilic cytoplasm. Polymerase chain reaction (PCR) for antigen receptor
gene rearrangement result of FNA sample revealed a T-cell malignancy. The cat died from acute renal failure after
1 cycle of modified Madison-Wisconsin L-CHOP protocol. Postmortem examination revealed bilaterally enlarged
lumpy-bumpy shaped kidneys. Histopathologic examination showed an infiltration of malignant lymphocytes into the
renal parenchyma and mesentery. Immunohistochemical staining of the renal sample displayed a negative expression
of CD3, PAX5, MUM-1, and CD79. The clinical features and prognosis of the cat with renal lymphoma with mesenteric
lymphomatosis have been described in this report.
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KEYWORD
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feline, lymphoma, acute renal failure, lymphomatosis
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